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LigASite database of binding sites |
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PDB ID and HEADER , TITLE and
COMPND records of the PDB file. | (click anywhere in this window to remove it) |
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1ade |
LIGASE (SYNTHETASE) |
HEADER |
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STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE PH 7 AT 25 DEGREES CELSIUS |
TITLE |
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ADENYLOSUCCINATE SYNTHETASE |
COMPND |
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Figure highlighting the binding site residues. Figures were drawn with
Molscript (7) and rendered with
Raster3D (8). PISA coordinates
(3) are used when available
(all entries except NMR). | (click anywhere in this window to remove it) |
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List of binding site residues detected in this protein. Column 1 gives the position, coloured on a yellow-to-red scale depending on the fraction of corresponding holo-structures where the residue is in contact with a ligand. Column 2 gives the 3-letter amino acid code, coloured according to physico-chemical type. Chain ID's of residues are not mentioned in this page because all chains in the apo-structure refer to the same protein. | (click anywhere in this window to remove it) |
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11 | |
TRP |
12 | |
GLY |
13 | |
ASP |
14 | |
GLU |
15 | |
GLY |
16 | |
LYS |
17 | |
GLY |
18 | |
LYS |
19 | |
ILE |
38 | |
ASN |
39 | |
ALA |
40 | |
GLY |
41 | |
HIS |
42 | |
THR |
44 | |
VAL |
| 49 | |
LYS |
114 | |
ASP |
126 | |
ILE |
127 | |
GLY |
128 | |
THR |
129 | |
THR |
130 | |
GLY |
131 | |
ARG |
133 | |
ILE |
134 | |
GLY |
143 | |
ARG |
223 | |
ALA |
224 | |
GLN |
225 | |
GLY |
228 | |
LEU |
| 237 | |
TYR |
238 | |
VAL |
239 | |
THR |
240 | |
SER |
267 | |
LYS |
272 | |
ARG |
273 | |
VAL |
274 | |
GLY |
275 | |
ALA |
293 | |
GLN |
294 | |
GLY |
295 | |
ASN |
296 | |
GLU |
297 | |
PHE |
298 | |
GLY |
| 299 | |
ALA |
300 | |
THR |
301 | |
THR |
303 | |
ARG |
305 | |
ARG |
330 | |
THR |
331 | |
LYS |
333 | |
ASP |
334 | |
VAL |
383 | |
PHE |
414 | |
SER |
416 | |
GLY |
417 | |
PRO |
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PDB |
The Protein Data Bank |
CSA |
Catalytic Site Atlas |
PDBSum |
Overview of the macromolecular structure |
CATH |
Protein Structure Classification |
Scop |
Structural Classification of Proteins |
Pfam |
Protein Families and Domains |
UniProt |
Universal Protein Resource |
LIGPLOT (only on holo-pages) is hosted at the EBI. The LigPlot Jmol links point directly to the Jmol visualisation interface provided on the PDBSum page. Note that due to different software used, the atomic contacts of LigPlot and LigASite do not necessarily correspond. | (click anywhere in this window to remove it) |
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Links to external databases: |
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Several files are provided for download: • The XML file defining the residue-ligand contacts; this file contains data on the apo and all holo-structures. |
• The XML Schema file defining the semantics of the XML file |
• 3D coordinates of the structure used in constructing LigASite (PISA structure file whenever available, PDB file otherwise. |
• 3D coordinates of the combined binding residues in the apo structure |
• 3D coordinates of the binding residues of the holo structure (only on the holo page) |
Coordinate files are in PDB format. | (click anywhere in this window to remove it) |
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Table describing the holo-structures and ligands used to define
the binding sites.
Column 1 gives the PDB ID of the holo-structure.
Column 2 gives the unique ID of the ligand;
a space-separated list of HET -groups that constitute
the ligand (see Methods).
Each HET -group in the ligand is uniquely identified by
a string in which the first four characters are the three-letter
HET ID from the PDB file followed by the chain ID from
the PISA file, and the last four characters are the residue sequence
number from the PDB file.
Column 3 gives the number of atoms in each ligand.
Column 4 gives the number of protein-ligand inter-atomic
contacts. | (click anywhere in this window to remove it) |
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pdb ID |
Ligand Unique ID |
#atoms |
#contacts |
1cg0 |
GDPB_432 HDAE_437 IMOC_440 _MGD_435 |
64 |
252 |
Details |
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GDPG_432 IMOH_440 HDAJ_437 _MGI_435 |
64 |
248 |
2gcq |
DOIG_451 _MGH_435 GDPF_432 HADE_437 |
63 |
244 |
Details |
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DOIC_451 HADA_437 GDPB_432 _MGD_435 |
63 |
244 |
1hoo |
GNHB_432 GNPC_432 |
60 |
176 |
Details |
1gim |
GDPG_432 HADF_438 IMPH_440 _MGI_435 NO3J_433 |
64 |
262 |
Details |
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GDPB_432 HADA_438 _MGD_435 IMPC_440 NO3E_433 |
64 |
264 |
1qf5 |
GDPB_434 _MGE_433 RPLC_435 PO4D_432 |
64 |
240 |
Details |
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GDPG_434 _MGJ_433 PO4I_432 RPLH_435 |
64 |
240 |
1qf4 |
GDPG_434 _MGJ_433 PO4I_432 RPDH_435 |
64 |
238 |
Details |
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GDPB_434 RPDC_435 _MGE_433 PO4D_432 |
64 |
237 |
1juy |
GDPB_432 H5PC_433 _PID_434 HDAF_438 _MGE_435 |
61 |
257 |
Details |
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GDPH_432 HDAL_438 _PIJ_434 H5PI_433 _MGK_435 |
61 |
263 |
1hon |
GNHB_432 |
28 |
134 |
Details |
1hop |
GCPD_433 |
32 |
128 |
Details |
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GCPB_432 |
32 |
134 |
1soo |
H5PE_453 SO4D_442 _NAF_547 SO4C_443 |
30 |
142 |
Details |
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H5PL_453 SO4K_442 SO4J_443 _NAM_547 |
30 |
146 |
1nht |
GDPC_432 PGSB_440 HADA_437 _MGD_435 |
64 |
267 |
Details |
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GDPG_432 _MGH_435 PGSF_440 HADE_437 |
64 |
257 |
1son |
AMPB_453 |
23 |
98 |
Details |
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AMPE_453 |
23 |
102 |
1cib |
GDPH_432 HDAK_437 _MGJ_434 IMPI_440 NO3L_433 |
64 |
253 |
Details |
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GDPB_432 HDAE_437 NO3F_433 _MGD_434 IMPC_440 |
64 |
256 |
1gin |
GDPB_432 IMPD_440 _MGC_435 HADA_438 NO3E_433 |
64 |
274 |
Details |
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GDPG_432 _MGH_435 IMPI_440 HADF_438 NO3J_433 |
64 |
274 |
1ksz |
GDPC_432 PGSB_440 HADA_437 _MGD_435 |
64 |
278 |
Details |
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GDPG_432 _MGH_435 PGSF_440 HADE_437 |
64 |
273 |
1ch8 |
GPXH_432 IMPI_440 NO3L_433 _MGK_434 HDAJ_437 |
67 |
254 |
Details |
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GPXB_432 NO3F_433 HDAD_437 IMPC_440 _MGE_434 |
67 |
255 |
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IMPI_440 NO3L_433 HDAJ_437 |
35 |
145 |
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v9.7 April 2012 |
Interdisciplinary Research Institute, Computational Biology, Villeneuve d'Ascq, France University College London, Biomolecular Structure and Modelling Unit, London, UK Hospital for Sick Children and University of Toronto, Structural Biology and Biochemistry Program, Toronto, Canada |
Script execution time: 0.1263 seconds |